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 | 名称: | anti- LIG4 antibody | 
|---|---|
| 货号: | FNab04774 | 
| 适应种属: | 人源,小鼠 | 
| 规格: | 100ug(微克) | 
| 状态: | 液体 | 
| 纯化方法: | 免疫亲和纯化 | 
| 纯度: | 经SDS-PAGE分析,纯度大于95% | 
| 宿主: | 兔 | 
| 亚型: | lgG | 
| 存储: | 用添加了0.02%叠氮化钠和50%甘油的PBS溶解,PH值7.3,可在-20℃下保存12个月(避免反复冻融) | 
| 免疫原: | ligase IV, DNA, ATP-dependent | 
| 分子量: | 100-104 kDa | 
| 验证应用: | ELISA, WB, IHC | 
| 建议稀释比例: | WB: 1:500-1:2000; IHC: 1:20-1:200 | 
| UniProt ID: | P49917 | 
| 克隆性: | 多克隆 | 
| 背景介绍: | Efficiently joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. Involved in DNA non-homologous end joining(NHEJ) required for double-strand break repair and V(D)J recombination. The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends. | 
| 图像: | ![]() Immunohistochemistry of paraffin-embedded human prostate cancer using FNab04774(LIG4 antibody) at dilution of 1:100。 
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