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| 名称： | anti- BRCA1 antibody |
|---|---|
| 货号： | FNab00942 |
| 适应种属： | 人源,小鼠 |
| 规格： | 100ug(微克) |
| 状态： | 液体 |
| 纯化方法： | 免疫亲和纯化 |
| 纯度： | 经SDS-PAGE分析,纯度大于95% |
| 宿主： | 兔 |
| 亚型： | lgG |
| 存储： | 用添加了0.02%叠氮化钠和50%甘油的PBS溶解,PH值7.3,可在-20℃下保存12个月（避免反复冻融） |
| 免疫原： | breast cancer 1, early onset |
| 免疫原别称： | RNF53 antibody |
| 分子量： | 85 kDa |
| 验证应用： | ELISA, WB, IHC, IF |
| 建议稀释比例： | WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:20 - 1:50 |
| UniProt ID： | P38398 |
| 克隆性： | 多克隆 |
| 背景介绍： | This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the f |
| 图像： |  Immunohistochemistry of paraffin-embedded human breast cancer using FNab00942(BRCA1 antibody) at dilution of 1:100。
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