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产品详情
| 名称： | anti- CD206 antibody |
|---|---|
| 货号： | FNab01442 |
| 适应种属： | 人源,大鼠,小鼠 |
| 规格： | 100ug(微克) |
| 状态： | 液体 |
| 纯化方法： | 免疫亲和纯化 |
| 纯度： | 经SDS-PAGE分析,纯度大于95% |
| 宿主： | 兔 |
| 亚型： | lgG |
| 存储： | 用添加了0.02%叠氮化钠和50%甘油的PBS溶解,PH值7.3,可在-20℃下保存12个月（避免反复冻融） |
| 免疫原： | mannose receptor, C type 1 |
| 免疫原别称： | CD206 antibody, CLEC13D antibody, Macrophage mannose receptor 1 antibody, Mannose receptor antibody, mannose receptor antibody, C type 1 antibody, MMR antibody, MRC1 antibody |
| 分子量： | 166 kDa |
| 验证应用： | ELISA, WB, IHC, FC |
| 建议稀释比例： | WB: 1:200-1:2000; IHC: 1:50-1:200 |
| UniProt ID： | P22897 |
| 克隆性： | 多克隆 |
| 背景介绍： | CD206, also named as MMR, CLEC13D and MRC1, is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. CD206 has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment. CD206 is a 170 kDa transmembrane protein which contains 5 domains: an amino-terminal cysteine-rich region, a fibronectin type II repeat, a series of eight tandem lectin-like carbohydrate recognition domains(responsible for the recognition of mannose and fucose), a transmembrane domain, and an intracellular carboxy-terminal tail. It is expressed on most tissue macrophages, in vitro derived dendritic cells, lymphatic and sinusoidal endothelia. This antibody recognizes the intracellular carboxy-terminal part of CD206 and MRC1L1. |
| 图像： |  Immunohistochemistry of paraffin-embedded human liver using FNab01442(MRC1 antibody) at dilution of 1:100。  mouse kidney tissue were subjected to SDS PAGE followed by western blot with FNab01442(MRC1 antibody) at dilution of 1:500。 |
