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| 名称： | anti- liver Arginase antibody |
|---|---|
| 货号： | FNab04801 |
| 适应种属： | 人源,大鼠,小鼠 |
| 规格： | 100ug(微克) |
| 状态： | 液体 |
| 纯化方法： | 蛋白A/G柱纯化 |
| 纯度： | 经SDS-PAGE分析,纯度大于95% |
| 宿主： | 小鼠 |
| 亚型： | IgG2a |
| 存储： | 用添加了0.02%叠氮化钠和50%甘油的PBS溶解,PH值7.3,可在-20℃下保存12个月（避免反复冻融） |
| 免疫原： | arginase, liver |
| 免疫原别称： | ARG1 antibody, Arginase 1 antibody, liver Arginase antibody, Liver type arginase antibody |
| 分子量： | 35 kDa |
| 验证应用： | ELISA, WB, IHC, IF |
| 建议稀释比例： | WB: 1:1000-1:8000; IHC: 1:200-1:1000 |
| UniProt ID： | P05089 |
| 克隆性： | 单克隆 |
| 背景介绍： | Arginase-1(Liver arginase) belongs to the arginase family. ARG1 is a novel immunohistochemical?marker?of hepatocellular differentiation in fine needle aspiration cytology and a marker?of hepatocytes and hepatocellular neoplasms. ARG1 is closely associated with alternative macrophage activation(PMID:12098359) and ARG1 has been shown to protectmotor neurons from trophic factor deprivation and allow sensory neurons to overcome neurite outgrowth inhibition by myelin proteins(PMID: 20071539).It can exsit as a homotrimer(PMID:16141327) and it has 3 isoforms produced by alternative splicing.Defects in ARG1 are the cause of argininemia(ARGIN). Deletion or TNF-mediated restriction of ARG1 unleashes the production of NO by NOS2, which is critical for pathogen control.(PMID:27117406). |
| 图像： |  Immunohistochemistry of paraffin-embedded human liver cancer tissue slide using FNab04801(ARG1 Antibody) at dilution of 1:50。  HepG2 cells were subjected to SDS PAGE followed by western blot with FNab04801(ARG1 Antibody) at dilution of 1:4000。 |
